Watch First: Six Films on Autism, Developmental Delay, ADHD and Mystery and Complex Diseases.

A History of the Mind

Understanding the mind in the making. A history of autism, attention, and the developing child, and what it means for families today. A Hope Health and Healing guide to autism, attention, and the developing child. This is an honest story about how some of the most talked-about conditions of childhood were first noticed, about how our understanding has changed, sometimes for the worse before the better, and where careful, considered medicine stands today. Part One. How these conditions were first seen.

The story begins in 1911, in the city of Zürich. It was there that the Swiss psychiatrist Eugen Bleuler coined the word autism for the first time, from the Greek word for self, to describe a profound withdrawal from the outside world. Bleuler was not describing children. For him, autism was a symptom of schizophrenia in adults. The idea we understand today, of autism as a distinct condition of childhood would not arrive for another thirty years. That early confusion, autism mistaken for a form of madness, would cast a long shadow over the children it eventually came to describe.

For much of the early twentieth century, children who were different were placed in large institutions, sometimes hospitals, sometimes long-stay wards attached to psychiatric asylums. They were separated from their families, excluded from schools, and, in perhaps the cruellest mistake of all, their conditions were blamed on their mothers. Then, in the summer of 1943, an Austrian-American psychiatrist working at the Johns Hopkins Hospital in Baltimore, named Leo Kanner, published a paper describing eleven children with what he called a previously unreported condition.

He gave it a careful new name: early infantile autism. A year later, in Vienna, a paediatrician named Hans Asperger described another group of children, children with real difficulties in social communication, but often striking language skills and unusual intellectual abilities. Autism, as we now know it, had finally been seen. The story of attention difficulties reaches back even further. As early as 1798, a Scottish physician named Sir Alexander Crichton described what he called a mental restlessness, "an inability to attend, with constancy, to any one task."

Nearly half a century later, in 1845, a German physician and poet named Heinrich Hoffmann published a book of illustrated children's rhymes called Struwwelpeter. It is best remembered today for one particular story, the story of Fidgety Philip, a little boy who could not sit still at the table and whose restless movements ended in disaster. It is thought to be the first widely known description of what we now call attention-deficit hyperactivity disorder, or ADHD. Then, in 1902, Sir George Frederic Still, England's very first professor of child medicine, gave the first serious medical account of the condition. And unusually for his time, he suspected the cause was not bad parenting, but biology.

Developmental and speech delays have a different origin altogether. Our very idea of what is normal and typical for a growing child was built in the 1920s by the American psychologist Arnold Gesell. Working with hundreds of infants, Gesell charted the ordinary milestones of childhood, when a baby sits, when they babble, when they crawl, when they take their first steps, when they say their first words. Milestones that we still use today. Part Two. How our understanding changed. For much of the twentieth century, these children were not truly understood.

They were hidden away in institutions, excluded from ordinary schools, and, in perhaps the cruellest mistake of all, their conditions were blamed on their mothers. The theory of the "refrigerator mother", the idea that autism was caused by cold or emotionally distant mothering, was popularised in 1967. It was a catastrophe for families. Mothers who were already struggling were told, wrongly, that they were the cause of their child's condition. This theory has since been completely, and rightly, discredited. A landmark study of identical twins, published later, showed that autism is strongly heritable.

The mothers were never to blame. Slowly, and against considerable resistance, the tide began to turn. From segregation to inclusion. From blame to biology. From simply managing behaviour, to caring for the whole child. The idea that variations like autism and attention difficulties are simply part of natural human diversity, what today we call neurodiversity, was given its name in 1998, and it has quietly reshaped how families, schools, and clinicians think about children. Part Three. Where we are now.

Today, more children than ever are being recognised as neurodivergent. In the United States, current data from the Centers for Disease Control and Prevention suggest that around one child in thirty-one is now identified as autistic. That is roughly five times the rate reported just two decades ago. Globally, the World Health Organization estimates the figure at about one child in every hundred. Around one child in nine is now understood to have attention-deficit hyperactivity disorder. And more broadly, roughly one child in six is thought to have some kind of developmental difference.

Closer to home, in the United Arab Emirates, recent published estimates place the rate of autism at approximately one child in a hundred and forty-six live births, and national screening programmes across the country are expanding. Here in Dubai, the official term for autism and other special needs is "people of determination." The term was created to change the way society looks at neurodiversity. It shifts the focus from disability to strength, resilience, and ability. It means people are not defined by a condition, they are defined by their determination, their potential, and their personality.

And it is United Arab Emirates official government policy. On the face of it, the rise in numbers looks alarming. But the honest answer is a hopeful one. Definitions have broadened, public awareness has grown, screening tools have improved, and many children who were once misdiagnosed, filed under a wrong label, or overlooked entirely, are now correctly evaluated and properly helped. Part Four. A moment to pause. The question of vaccines. No honest history of autism can avoid the question that has worried more parents than almost any other. Could vaccines play a part?

It is a fair question, asked in good faith, and the honest answer needs to be given with care and context. Vaccines protect children without doubt, from measles, whooping cough, diseases that if and when they return can cause serious illness and, in rare cases, death. That benefit is real, and it is measurable. Thoughtful parents ask a more nuanced series of questions, typically three distinct questions. They ask about the measles, mumps and rubella combination vaccine. They ask about the total schedule of injections.

And they ask about the age at which vaccination begins. Each of these questions has been carefully studied. On the single measles, mumps and rubella vaccine, the research evidence across many millions of children does not show a link with autism. On the total schedule, the studies to date are similarly reassuring, although some very specific combinations have not been tested head to head, and any honest science must remain humble about what it has not yet fully examined. Our position is not to dismiss these questions, and not to inflame them either.

It is to take them seriously. Each and every family deserves an unhurried, respectful, informed conversation with an experienced clinician who knows their child, their history, their development, and their family. Not a lecture. Not a dismissal. A genuine conversation. That is the kind of conversation we believe every family is entitled to, and one they will always receive at Hope Health and Healing. Part Five. A sudden storm. PANS and PANDAS. There is one more chapter to tell, the youngest of them all, and perhaps the most debated and contested.

Some parents can describe the exact day their previously well child suddenly changed. A ferocious, sudden onset, almost overnight, of tics, anxiety, and a sudden collapse in school performance. In 1998, researchers at the United States National Institute of Mental Health, led by Dr Susan Swedo, described fifty such children and named the pattern they saw as PANDAS. That stands for Paediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections. A broader term, PANS, standing for Paediatric Acute-onset Neuropsychiatric Syndrome, was added in 2012, for sudden-onset cases not linked to streptococcus infection.

The believed mechanism is both scientifically logical, and, once explained, quite intuitive. When the body fights an infection with the bacterium known as Group A Streptococcus, the same bacterium that causes strep throat, it produces protective antibodies. In a small number of children, those antibodies do something unexpected. They cross-react with a small cluster of structures deep in the brain, called the basal ganglia. The basal ganglia are a network of grey-matter nuclei that sit beneath the cortex, and they help govern movement, learning, mood and behaviour.

The scientific name for this confusion is called molecular mimicry. Put simply, molecules on the surface of the bacteria look, to the immune system, very much like molecules on the surface of healthy brain cells, and so antibodies made to fight the bacteria can mistake those brain cells for the invader. They attack and fire on the wrong target. It is, in effect, friendly fire. The body winning one battle, a bacterial infection, while accidentally starting another. The science remains under active study, but the hypothesis itself is hopeful.

Because inflammation in the brain, unlike a permanent condition, is something medicine can very often treat successfully, and calm. Traditional guidance often begins with talking therapy, or with conventional medication. But when a child's symptoms are being driven by an underlying immune process, these approaches can bring very little benefit, and in the meantime, valuable months of a child's life can be lost. The most important first step is a careful conversation with an experienced clinician who is familiar with the full range of options.

That includes intravenous immunoglobulin therapy, sometimes called IVIG. It is a gentle infusion of protective antibodies, intended to help settle a misdirected immune response. In one carefully conducted study, available in the full article on our website, nine out of every ten severely affected children responded to treatment. Symptom scores fell by more than forty per cent, and school absences dropped from nearly ten days each month to fewer than three. Part Six. The view from Hope. All of this history leads us to a single, hopeful idea.

And it is the idea that guides our work every day, at Hope Health and Healing Medical Center in Dubai. For many children, autism, developmental delay, and speech delay are not simply behaviours to be managed. They are conditions with underlying medical contributors that deserve thorough, careful investigation, and treatment. Our medical director is Dr Lilya Chub, board-certified in family medicine and neurology, with nearly thirty years of international clinical experience, and a subject-matter expert in neurodivergent child diagnosis and whole-child care.

She is joined by Dr Hiba, professor of neurology and consultant in internal medicine and neurology, an expert in the medical specialty of the brain and nervous system. Dr Hala, professor of clinical immunology, an expert in immune-directed therapy, the medical specialty of the body's immune system and its treatment, including immunoglobulin therapy. And Raya Abu Younis, our clinical nutritionist. She holds a master's degree from Imperial College London, one of the world's leading universities. She is a specialist in paediatric nutrition and supplementation, supporting children's growth, development and recovery through food and nutrition.

Together, this team investigates the whole child, inflammation in the brain, imbalances in the immune system, nutritional deficiencies and vitamin insufficiencies, disturbances of the gut and its microbes, and, where relevant, exposure to environmental toxins, including heavy metals. A case that stays with us. The boy who found his voice. One case that we often think about is that of a young boy. When he first came to us at Hope Health and Healing, aged just four, his story was quite dramatic.

He was completely non-verbal. He was hyperactive and restless. He made almost no eye contact. He did not even react to his own name. He was severely bloated, and constipated. He had life-threatening food allergies to seafood and to oats. He was not toilet-trained. He suffered from severe insomnia, waking most nights, and, on some days, spending three or four hours simply running around the house. His ATEC score, on the Autism Treatment Evaluation Checklist, was one hundred and ten.

That is severe autism. A truly comprehensive investigation followed. Detailed testing revealed an extraordinary range of food intolerances. His stool analysis showed almost no beneficial bacteria, and a significant fungal overgrowth. Urine testing revealed very high levels of lead, mercury, and other heavy metals. The treatment protocol was equally comprehensive. A carefully tailored exclusion diet. Antifungal treatment. Probiotics and gastrointestinal support. Chelation therapy for six months, to remove the heavy metals. And targeted nutritional supplementation, of vitamins, minerals, and neurotransmitter precursors.

Within just the first few months of treatment, his bowel movements normalised. His bloating disappeared. His eye contact returned. His first words came. And within three months of those words, he was speaking in short phrases. Today, he is seven years old. He attends a mainstream school and requires no additional teaching support. He excels in reading, mathematics, and grammar. He speaks three languages fluently. And he is described by his parents and by his teachers, as "very talkative". At Hope Health and Healing, we do not promise cures, and every child is different.

But what we do promise, always, is to investigate properly, and to care for the whole child. Where others have stopped looking, we look deeper. The full article, Understanding the Mind in the Making, is available to read on our website at hhhmed.com. It is fully and richly referenced, with a comprehensive list of sources, should you wish to explore any part of what you have heard in greater depth. And you may also download the article, as a PDF, or as a digital download for your favourite e-reader, such as Apple Books, or Kindle.

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النص العربي  |  تاريخ العقل

About this transcript. The English is the words spoken in the film. The Arabic is a written translation prepared for reading, and it has been checked and corrected for this page, so in a few places it is worded more fully than the subtitles on screen, which were written to be read quickly while the film plays. This page carries the complete wording.

عن هذا النص: النص الإنجليزي هو الكلام كما ورد في الفيلم، أما النص العربي فهو ترجمة أُعدّت للقراءة، وقد رُوجعت وصُحِّحت للنشر في هذه الصفحة. ولذلك جاءت صياغتها في مواضع قليلة أكثر تفصيلاً من الترجمة الظاهرة على الشاشة، التي كُتبت لتُقرأ بسرعة أثناء عرض الفيلم. وهذه الصفحة تحمل الصياغة الأكمل.