Neuropeptides belong a class of protein-like molecules made in the brain. Neuropeptides consist of short chains of amino acids, with some functioning as neurotransmitters and some functioning as hormones.
In recent years the study of neuropeptides has become a relevant area of research, dedicated to recovery functions of brain tissue during stress, ischemic damage and neurodegenerative diseases.The main mechanisms of action of neuropeptides are:
- The regulation of brain energy metabolism, the maintenance of redox balance
- Their own neurotrophic influence and modulation of the activity of endogenous growth factors
- Interaction with systems of neuropeptides and neurotransmitters
Despite the possibility of proteolysis, neuropeptides, unlike typical neurotransmitters, can function in the body for several hours.Neuropeptides are successfully used to treat:
- Vascular encephalopathy
- Post-poisoning conditions including heavy metals toxicity
- Ischemic states of the brain
- Post-inflammatory encephalopathies and encephalitis
- They increase stress resistance and improve an overall brain performance
One of the major effects of neuropeptides is their normalizing ability of energy metabolism and free radical oxidation, which is usually accompanied by an increase in cellular and humoral immunity, improvement of coagulation indices, increase of neuronal activity, optimization of cognitive functions, etc. Depending on the place of their release, neuropeptides can carry out a mediator function, modulate the activity of certain groups neurons, stimulate or inhibit the release hormones, regulate tissue metabolism. Peptide bioregulators are involved in maintaining the structural and functional homeostasis of cell populations, control gene expression and protein synthesis in cells. Neuropeptides are able to regulate the activity of pro- and anti-inflammatory cytokines by modulating the activity of their receptors. In this case, the restoration of the normal balance of cytokines occurs more efficiently, than when exposed to individual cytokine systems.
Cytokine effects of neuropeptides typically are accompanied by their influence of the of nitric oxide production and other oxidative processes. Many neuropeptides exhibit pronounced neurotrophic growth properties. Due to the fact that neuropeptides are the endogenous regulators of the central nervous system functions, they have a number of advantages over other groups of neuroprotective drugs:
- High physiological activity
- The presence of several binding groups for different cell receptors and ability to regulate expression of other signaling molecules
- Short half-life and minimum side effects
- The ability to penetrate the blood-brain barrier
- The presence of trophic, growth, anti-inflammatory, mediator and effector properties
- Even when used in small doses they exhibit neuroprotective activity
- No or very minimal side effects
- Eery low toxicity
In a clinic, neurotropic peptides can be used in the form of intravenous or intramuscular administration.
But recent comparative analysis of the effectiveness of neuropeptides for different routs of administration (intramuscularly, intraperitoneally, intravenously, intranasally, subconjunctival-nasal) into the body showed that the nasal form of administration can be the same effective way of introducing neuropeptides as IV or IM.
Among most known and well-researched neuropeptides are Selank, Semax, Cortexin, Сerebrolysin, Deltaran, Thymosin- alpha.
In our Hope Health & Healing Medical Center, you will be advised for the most reasonable and effective neuropeptide treatment option, optimal duration and frequency of medication use.
The entire course with neuropeptides treatment in average takes 14-30 days and can be repeated in 3-4 months.