What is Methylation and why do we need to support it

Methylation recently became a hot topic in connection to understanding epigenetics mechanism.  Epigenetics is a science or art about how our genes are expressed. We tend to forget that our genes get turned off or on at different times in our lives. For example: some are turned on in adolescence, some in pregnancy. Some genes need other environmental factors before they are unlocked by the body.

Methylation is a process that uses a series of enzymes to transfer a little carbon group, called a methyl- group (four atoms - one carbon atom and three hydrogen atoms (CH3) from one substance to another.  Methylation is used as a locking mechanism for DNA, basically turning on and off genes, which helps appropriate division and formation of immune, gut and hormone producing cells. And because the body is very smart, this one process is used for other important body reactions- like detox, or even making neurotransmitters. With enough starting products and vitamins and mineral cofactors, the methyl- group can be recycled to be used again and again.

How Does Methylation Work?
CH3 is provided to the body through a universal methyl donor known as SAMe (S-adenosylmethionine). SAMe transfers its methyl group to other substances in the body, which enables the cardiovascular, neurological, reproductive, and detoxification systems to perform their functions. But the system that produces SAMe depends only on one gene, which can be switched off or on easily by a critical B vitamin-active form of Folic acid, or 5- Methyl-Hydro-Tetra-folate (5MTHF)
So, if you have enough of 5-MTHF, the methylation cycle will work efficiently. Folic acid from the diet or supplements must be converted to this active form, 5-MTHF, before it can be used in the body in the methylation cycle. Unfortunately, as it is estimated and proved now, approximately 60% of people have a genetic mutation that makes it very hard for their cells to create enough 5-MTHF.

When the methylation switch is turned off and isn’t creating enough SAMe, then a number of important molecules cannot be efficiently produced, including:
  • Glutathione
  • Coenzyme Q10
  • Melatonin
  • Serotonin
  • Nitric Oxide
  • Norepinephrine
  • Epinephrine
  • L-Carnitine
  • Cysteine
  • Taurine
  • Migraines
  • Ringing in the ears
  • MS and other autoimmune disorders
  • Chronic Immune infections
  • Poor healing
  • Mood concerns (depression, anxiety)
  • Autism Spectrum Disorders
  • Chronic Fatigue and Fibromyalgia
  • Midline defects
  • Fertility concerns
How we can manage?
We have now a simple and easy genetic test to find out if you have a problem with methylation cycle. This test checks out specific enzymes that are affected by impaired genome, including the enzyme MTHFR (methylenetetrahydrofolate reductase), which is the most important enzyme involved in creating 5-MTHF.

In addition to a healthy, whole-food, non-processed food diet, make sure you are eating a lot of these foods:
  • Asparagus
  • Avocado
  • Broccoli
  • Brussels sprouts
  • Green, leafy vegetables
  • Legumes (peas, beans, lentils)
  • Rice
Lifestyle changes include:
  • Engage in regular physical exercise
  • Avoid excessive alcohol consumption
  • Don’t smoke
  • Avoid excessive coffee consumption (not more than five cups daily)

We are at HHH Medical Center will help you to find out if you have methylation problems, will create the correct protocol for you to balance the necessary  vitamins and supplements  which will ensure your methylation to perform optimally.